classical complement pathway การใช้

• The binding of XNAs initiate complement activation through the classical complement pathway.
• Three biochemical pathways activate the complement system : the classical complement pathway, the alternative complement pathway, and the lectin pathway.
• Three biochemical pathways activate the complement system : the classical complement pathway, the alternate complement pathway, and the mannose-binding lectin pathway.
• MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor.
• All pathways culminate in the production of a C3 convertase, which catalyses C3 into its constitutive parts ( better detailed here-classical complement pathway ).
• However it inactivates certain other serine proteases that are not involved in coagulation such as trypsin and the C1s subunit of the enzyme C1 involved in the classical complement pathway.
• This is important for targeting the virus in its intracellular phase because the antibodies specific to the synthetic peptides can trigger the classical complement pathway and induce the death of HIV infected cells.
• The most common form of the disorder is HAE type I, which is the result of abnormally low amounts ( low the C1 part of the classical complement pathway from being overactive ).
• The classical complement pathway typically requires antibodies for activation and is a specific immune response, while the alternate pathway can be activated without the presence of antibodies and is considered a non-specific immune response.
• The protein resembles antibody and performs several functions associated with host defence : it promotes agglutination, bacterial capsular swelling and phagocytosis, and activates the classical complement pathway through its calcium-dependent binding to phosphocholine.
• Animal studies performed in India show ingestion of a defatted alcoholic extract of " Boswellia " decreased polymorphonuclear leukocyte infiltration and migration, decreased primary antibody synthesis and almost totally inhibited the classical complement pathway.
• The classical complement pathway typically requires antigen antibody complexes ( immune complexes ) for activation ( specific immune response ), whereas the alternative pathway can be activated by C3 hydrolysis, foreign material, pathogens, or damaged cells.